Multiple sclerosis (MS) is the first non-traumatic cause of neurological disability in adults under 40 years. It is estimated to affect about 2.5 million people worldwide, with a ratio of women / men 3: 1.
Origin of multiple sclerosis
The origin of MS is unknown, although it is accepted that it is an illness with two components: one-autoimmune inflammatory, driven mainly by activated T-CD4 lymphocytes hematoencefálcia passing the barrier, resulting in sequential lesions (temporal dispersion) and patched degenerative (spatial dispersion), usually located in the white matter of the central nervous system (CNS), and another that leads to irreversible neuronal axonal damage. Both processes are present from the onset of the disease, but its intensity varies from one subject to another, which together with other reparative potential of each individual, make your course is highly variable and unpredictable evolution.
Diagnosis and treatment of multiple sclerosis
There is the belief that early diagnosis and treatment of MS diminish the accumulation of lesions and the degree of disability, which depends on axonal damage and consequent atrophy. Thanks to the contribution of magnetic resonance imaging (MRI), the disease can be diagnosed with high reliability when the first symptoms of neurological dysfunction -the called insulators demyelinating syndrome occur because injuries can prove different location and different developmental stages, revealing the two essential aspects of the disease.
Evolution of multiple sclerosis
MS may have an initial course of flares and remissions (relapsing-remitting), with episodes of neurological deficit recover fully or partially; half of patients with this form will start to present a progression of disability independent outbreaks (secondary progressive form). In about 15% of cases, a gradual increase in disability from baseline (primary progressive form, which can be superimposed promptly shoots) occurs. He is currently attached great importance to the presence of Gd lesions FDG uptake in the MRI study, and translating activity.