Scleroderma is an autoimmune disease that causes hardening of the skin and changes in blood vessels, muscles and internal organs. The origin of the disease is unknown, but the patients have in common the accumulation of a fibrous protein (collagen) in the skin and other organs. The main symptom of scleroderma is swelling and hardening of the skin, and inflammation and scarring in many parts of the body that cause problems in other organs. The disease can occur in severe form, even to cause death or mild form in which it manifests itself only in a localized way. Therefore, we differentiate between two types of scleroderma. One is localized scleroderma only affects parts of the skin, usually the hands and face. The other is scleroderma or progressive systemic sclerosis, which can affect the whole body (skin, esophagus, lungs, heart ...). This type of scleroderma disease is divided into diffuse and limited disease or CREST syndrome, which presents five typical features: calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly and dilation of small vessels. Treatment of the disease depends on the type and severity of symptoms.