Or Dupuytren Dupuytren's disease is a chronic disease of unknown origin that causes the progressive closure of the hand. The first symptom of the disease is the appearance of a hard lump (like a callus) in the area of the folds of the palm annoying but not painful. Gradually the nodule becomes a rope that is spreading to the fingers and hand is closing. In the final stage of the disease the affected person can not open his hand, so he has difficulty picking up objects and even for the hygiene of the same. Dupuytren treatment may be surgery, radiotherapy, or based on an experimental technique using collagenase injections. From the outset, the Dupuytren could deal with physiotherapy to restore functionality of the hand, gain strength and mobility, and maintaining both the skin and the scars in the best possible condition.