What is La Peyronie's disease?
La Peyronie's disease or plastic induration of the penis is a process of unknown cause characterized by a plaque or scar on the penis that grows below the skin of the penis and produces an incurvature during erection. This fibrosis or scar that produces is an attraction of the penis during the erection and is what causes the curvature of the same. This incurvation at the beginning is painful and then this type of pain is disappearing. This disease is usually unilateral and occurs mainly in men between 50 and 70 years of age.
Why does this disease occur? What treatments are there?
It is not known why La Peyronie's disease occurs. It can often result from trauma during penetration, although many studies link the disease to an abnormal immune system or abnormal scarring. This disease has a very variable evolution, but in most patients it is usually progressive until that scar is stabilized and the patient reaches a certain degree of curvature. The goals of treatment are to relieve pain, improve the degree of curvature and allow penetration during sexual intercourse. Most of the treatments that have been tried throughout history are totally ineffective and do not have any scientific evidence. At the beginning you can always try a type of medical treatment and ultimately the definitive treatment until now has been surgery. Lithotripsy or low energy shock waves, applied to the penis, act in the pain phase, decreasing or making the pain disappear. But already when the curvature is fully established so far the only definitive treatment was surgery. The problem of surgery in La Peyronie's disease is a complex surgery and, in addition, in many cases, it produces a significant shortening of the penis.
What is Peyroflex treatment? How does it act?
The FDA or the Ministry of Health of the United States of America approved the first drug for La Peyronie's disease in 2013. Now finally comes to Spain, from the hand of Laser Medical Rent this drug that will prevent surgery in many cases. Peyroflex is the first non-surgical alternative for the treatment of La Peyronie's disease in patients with a degree of curvature greater than 30 degrees. Peyroflex is a biological medicine extracted from the histolytic clostridium toxin. Peyroflex acts through some injections that we make in the plaque, undoing the accumulation of collagen or that scar.
How the treatment is applied? Is it safe and effective?
The treatment consists of several cycles. The first day the drug is injected into the plate. More or less at 48 hours after the first injection, a second injection is injected into the area of the plate. And at 48 there is a modeling of the penis to try to break the plate. After this treatment the patient is taught a series of exercises that must be done at home for at least six weeks. At the end of this period the patient is reevaluated and in many cases a second or third treatment cycle is needed. The safety and efficacy of Peyroflex has been established in two large studies with more than 832 patients who had a degree of curvature greater than 30 degrees. In most cases the degree of curvature improved by more than 40 or 50 degrees. Therefore, treatment with Peyroflex significantly reduced the degree of incurvature and the annoying effects related to the disease.