Growth factors and rheumatology

Written by: Dr. Jaume Graell i Massana
Edited by: Top Doctors®

Growth factors are proteins that are in all the cells of the body, the richest are the platelets of the blood. They are in an inactive state, when there is an external aggression they activate and their function is to stimulate the regeneration of organic tissues in general, but also, in recent years it has been discovered that they have a very important anti-inflammatory action.


Applications of growth factors

The most common applications are in knees and hips, but also in tendinosis of the shoulders or other locations and, lately in the spine. Any degenerative, joint, muscular or tendinous problem.


Growth factors are proteins that are in all the cells of the body


The technique involves taking a small amount of blood, which is usually like an analysis, and centrifuging it to separate the plasma from the red blood cells.. The platelet-rich plasma is recovered and we obtain the cells that bring more growth factors, but which are inactive.

The activation of growth factors occurs by adding calcium chloride, which the body already produces naturally when there is a trauma, but we have to apply to produce activation, and this plasma with the activated factors we apply in the area that we want to try. It is a very simple technique, even more, because now it can be done in the same act, the patient draws blood, centrifuges, follows the whole process and makes the application.


Treatment duration

Experience indicates that when large joints are treated, especially those of load: knees and hips, the best way to obtain a response is to make four applications with about 3-4 weeks of rest between each of the first three applications. the two months we do the fourth session, what we call a reminder. In other locations the most frequent are three applications.


Benefits of growth factors

Rheumatologists try to delay or avoid surgery. We intend to vary the evolution of the degenerative processes of the tendon or cartilage, which we know that when it begins its progression does not stop, and we try to modify this evolution to make the cartilage more resistant. Another objective is to improve the symptomatology of the patient, reducing inflammation and the pain he suffers.


More information about the treatment at

*Translated with Google translator. We apologize for any imperfection

By Dr. Jaume Graell i Massana

Expert in fibromyalgia and osteoarthritis. Founder and director of the Institut Català de Reumatología, after holding positions of responsibility in various centers, he has always been in charge of the rheumatology service. He expanded his training in the United States and Germany, and today is a renowned speaker at different national and international conferences.


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*Translated with Google translator. We apologize for any imperfection

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